Axonal & neuronal neuropathy (AMAN) is a variant of Guillain-Barré syndrome, an autoimmune disease. It is characterized by acute paralysis and loss of reflexes without sensory loss. The syndrome typically presents as a progressive symmetric paralysis (loss of muscle function) with areflexia (absence of neurologic reflexes such as the knee jerk reaction), often causing respiratory failure. Antibodies attack the coating of the motor neurons without causing inflammation. It does not affect sensory neurons, so sensation remains intact despite loss of movement.
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